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Liver Longer: Liver Support for 17-alpha alkylated Steroid Users
Have you ever used oral Anabolic Steroids such as Dianabol, Anadrol, Winstrol,
Halotestin, etc.? What about over the counter pro-hormones like Pheraplex,
Halodrol, Superdrol, etc.? If so, your health could be in serious trouble. All
of these products, (and more), can cause serious liver toxicity. The three main
types of hepatotoxicity seen clinically from the use of oral steroids include
intrahepatic cholestasis, peliosis hepatis, and hepatic adenoma. None of them
are pretty and can lead to serious health problems such as jaundice, heart
disease, liver failure, cancer or even death.
There is however some very good news concerning all of this. Interestingly, all
three of these toxicities are believed to be related, stemming from cholestasis.
Cholestasis occurs when the 17-hydroxyl group of the oral steroid enters the
liver and it becomes glucuronidated, slowing down bile flow and sometimes
stopping it completely, this slowing of bile is the cause of all the previously
mentioned liver problems from oral steroid use. The active ingredient in Liver
Longer™ is a noncompetitive inhibitor of steroid glucuronidation, research has
shown the ingredient in Liver Longer™ will prevent the slowing of bile passing
through the liver and thus prevent toxic metabolites from being formed. In
addition Liver Longer™ may increase the excretion of any glucuronide metabolites
that do get formed, so they will not be around long enough in the liver to start
down regulating any bile acid transporters that could lead to disease.
Liver Longer™ from ThermoLife International is a breakthrough product,
specifically targeting steroid toxicity, and is not a run of the mill liver
protector. Liver Longer™ was developed to prevent the formation of toxic steroid
metabolites, reverse the toxic actions of the metabolites that do get formed and
speed the elimination of the metabolites from the liver. If you have recently
taken any oral anabolic steroid, either in an over the counter supplement or
pharmaceutical (black market) form, you need to be taking Liver longer™ to
protect your self. ThermoLife International is the first and only company to
bring this unique product to market. Get yours today and Liver Longer Life!
Liver Longer (more technical information):
Anabolic steroids have a reputation for being very harmful for people to use. In
reality, the side effects of anabolic steroid use are generally overstated by
the media and also by most healthcare professionals. The common protocol is to
throw out a laundry list of side effects to describe the “evils” of steroid use.
While steroids are neither deadly nor harmless, some are better than others with
regards to health. Specifically, steroids that are modified at the 17-alpha
position with an alkyl group are responsible for the majority of negative side
effects attributed to steroids in general. Although these steroids are sometimes
injected, they are commonly considered oral steroids.
The good:
For bodybuilders and athletes, oral steroids are able to sneak past the liver to
get into the bloodstream. This is good and bad thing, however. It’s good because
this allows the ingested steroid to remain active after passing through the
liver. This is in contrast to non-modified steroids, which are rapidly
metabolized to inactive steroids. The modification becomes advantageous for
those who do not use injectable steroids or who wish to add additional types or
amounts of steroids to an injectable protocol.
The bad:
The downside to the alkyl modification of the steroid is that it allows for the
steroid to become liver toxic. The reason the modified steroids become liver
toxic is because the steroid is able to form 17-glucuronide metabolites.6 These
metabolites are the culprits when it comes to oral steroid liver toxicity.
The ugly:
There are three main types of hepatotoxicity seen clinically from the use of
oral steroids. These include intrahepatic cholestasis, peliosis hepatis, and
hepatic adenoma. Cholestasis is the most common side effect seen, with peliosis
and adenoma being much less common. Cholestasis occurs when bile flow through
the liver is impaired. When this happens, products that are normally carried in
the bile to the gut and excreted begin to build up within the liver. These
products can reach toxic levels and cause cell damage and death. Monitoring for
liver enzymes such as AST and ALT could detect if damage was occurring in the
liver. Cholesterol metabolism becomes impaired as a result of cholestasis, with
an increase in LDL (Bad cholesterol) and decrease in HDL (Good cholesterol).2
These cholesterol changes may lead to an increased risk of heart disease, and
are very common with oral steroid use. HDL below 10ng/dl is not uncommon to hear
about. That’s bad considering the desired level is greater than 40ng/dl!
Finally, jaundice may occur. What essentially occurs is a buildup of bilirubin,
which is formed when red blood cells break down. Since it cannot be excreted in
the bile, it essentially backs up into the body and causes a yellowing of skin
and eyes. This is not something you want to see!
Peliosis hepatis is characterized by blood filled cavities within the liver.
Rupture of these cavities may lead to death or liver failure. Hepatic adenoma
usually presents as a benign tumor, which may become malignant or interfere with
hepatic function as well.
There is some very good news concerning all of this. Interestingly, all three of
these toxicities are believed to be related.6 Cholestasis, over time and left
unchecked, is believed to lead to the more serious side effects.5,6 It’s a
progression that can occur over time with prolonged use. This also means that if
you could prevent cholestasis, you could prevent the complications from that, in
addition to the other risks as well!
Can it be done? We believe it can be done!.
LIVER LONGER™ specifically addresses steroid toxicity in several unique ways.
While there are other good “liver protector” products available, they are more
for general liver health than anything. What sets this product apart is that it
is SPECIFICALLY for promoting healthy liver function in the presence of oral
steroids.
So how, specifically, do oral steroids cause cholestasis, and thus toxicity? As
the steroid enters the liver, it becomes glucuronidated. This means a glucuronic
acid molecule is attached to the 17-hydroxyl group of the steroid. The intended
purpose of this is to make the steroid more water soluble so it can be excreted
in the urine. That is what is supposed to happen, but these glucuronides tend to
accumulate in the liver, where they are believed to act upon orphan receptors to
cause a down regulation of bile acid transporters.1,6 Bile acid transporters are
the most important factor for bile flow in the liver, and when these
transporters disappear because of the steroid, bile flow stops and trouble
starts.
If you had cholestasis and you went to the doctor, you would probably get a
prescription for a drug called Ursodiol. This is the brand name for the bile
salt ursodeoxycholic acid (UDCA). UDCA would not be a bad choice for prevention
of toxicity, but there are a few problems. First, it requires a prescription
because it’s a drug. Second, even if you found some on the black market, it’s
awfully expensive.
Fortunately, there is a better choice. The substance in question is
tauroursodeoxycholic acid or TUDCA for short. It is the taurine conjugate of
UDCA. TUDCA is an endogenous bile acid accounting for a small percent of the
bile found in the human body. It has been used traditionally as well, being
found in bear gall bladders, to treat liver disorders for many years.
TAUROURSODEOXYCHOLIC ACID (TUDCA)
There are multiple ways TUDCA aids in normal liver function. First, this bile
acid acts to restore bile acid transporters. Doing this allows bile to flow
normally via these transporters. Not only that, but it also acts to prevent
formation of the toxic steroid glucuronides in the first place. A 2003 study
showed that TUDCA noncompetitive inhibitor of steroid glucuronidation in vivo
and in vitro.3 This means fewer toxic metabolites will be made in the first
place! As if that one-two combination was not good enough, TUDCA may increase
the excretion of any glucuronide metabolites that do get formed, so they will
not be around long enough in the liver to start down regulating any bile acid
transporters.4
So you can see this product is extremely targeted toward steroid toxicity, and
is not a run of the mill liver protector. It helps prevent the formation of
toxic steroid metabolites, reverses the toxic actions of the metabolites that do
get formed, and speeds the elimination of the metabolites from the liver.
While we do not advocate the use of steroids, the reality of it is that many
people use these products, often without medical supervision. A product such as
Liver Longer would be extremely valuable as a health protective measure to
anyone who did choose to use oral steroids, whether they are legal dietary
supplement or illicit black market or prescription products.
Liver Longer Supplement Facts
Serving Size: 2 Tablets
Servings per Container: 60
Amount per Serving
Tauroursodeoxycholic acid (TUDCA) 250mg
Liver Longer Suggested Use:
As an adult dietary supplement take one (1) tablet twice daily with meals.
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