ThermoLife Stizm, 90 Caps

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Stizm: Extreme Energy Inducing Formula

Tyramine
Tyramine is a trace amine found naturally in the body, as well as many "old" foods, like salami, cheese, red wine, e.t.c. Tyramine acts by replacing catecholamins like adrenaline and dopamine in the post-senaptic neurons, thus resulting in catecholamine release.[16] Recent research indicates that tyramine might also act as a neurotransmitter. This hypothesis comes from the discovery of a G protein-coupled receptor with high affinity for tyramine called TA1[17]

Octopamine
Just like synephrine which stands apart from adrenaline only due the reduction of an –OH group, octopamine is almost similar to noradrenalin, with the exclusion of a phenolic hydroxyl group. This makes the molecule more capable to bypass the blood brain barrier and affect the C.N.S. compared to normal noradrenalin. Also the lack of a methyl group at the nitrogen, gives it equal alpha and beta adrenergic properties. Because it lacks the m-placed hydroxyl group, octopamine, like synephrine, isn’t metabolized by COMT, thus having a longer half-life and bioavailability. Indeed, in animal in-vivo studies oral octopamine has demonstrated capability to stimulate both alpha and beta adrenergic receptors(18,19). However it quite selectively stimulates beta-3 adrenergic receptors, which promote lipolysis, instead of beta-1 and beta-2 receptors[20,21,22]. In animal studies, octopamine has also demonstrated capability to elevate mood, increase blood pressure and enhance locomotor activity[23,24]

Hordenine
Hordenine is a naturally present amine in many roots of plants of the Graminae family. The lack of a hydroxyl group in the carbon chain gives it indirect sympathomemetic abilities, like amphetamine. The dymethylation of the nitrogen atom also gives it slight MAO inhibiting properties, but hordenine seems to be a selective MAO-B inhibitor. MAO-B metabolizes dopamine and thus it’s inhibition has no great effect in blood pressure, but can elevate mood. Experiments in intact animals (rats, dogs) show that hordenine has a positive inotropic effect upon the heart, increases systolic and diastolic blood pressure, peripheral blood flow volume, inhibits gut movements but has no effect upon the psychomotorical behaviour of mice. Also hordenine is a very potent diuretic and although it can initially heighten blood pressure, over time it’s diuretic effect lowers blood pressure.[25]

Phenylethylamine(PEA)
Of all the endogenous trace amines, phenylethylamine is the one most closely structural to amphetamine. It is a major psychotropic constituent of chocolate and is speculated to be released in great amounts by the brain when in love[16]. Recent research has identified 15 members of two distinct families of G protein-coupled receptors with a high degree of similarity to traditional G protein-coupled biogenic amine receptors. It was demonstrated that one of these receptors, called TA1, is a receptor for two of the trace amines, â-phenylethylamine and tyramine. TA1 binds to both â-phenylethylamine and tyramine with high affinity and produces cAMP in response to this binding, whereas the related TA2 receptor appears to be specific for â-phenylethylamine and tryptamine. Both of these G protein-coupled receptor families possess many of the structural hallmarks of the rhodopsin/â-adrenergic receptor superfamily[17]. Apart from affecting it’s own receptors, phenylethylamine can also enhance the impulse-propagation mediated release of catecholamine and serotonin[26], although research has indicated that tryptamine possesses greater capability of promoting serotonin release(thus elevating mood) while PEA promotes noradrenaline release(thus stimulating the CNS). Phenylethylamine has shown in research to elevate mood [27,28,29,30] but the biggest challenge has been it’s relatively low half life, since it is rapidly metabolized by MAO-B. However the inclusion of a MAO-B inhibitor like hordenine can lengthen it’s half-life and effectiveness.[31]

Warning: Not intended for use by anyone under the age of 18. Do not use this product if you are pregnant, nursing or contemplating pregnancy. Do not use this product if you have any medical condition especially heart disease, thyroid disease, diabetes, high blood pressure, psychiatric condition, difficulty in urinating, prostate enlargement, or seizure disorder, if you are using a monoamine oxidase inhibitor (MAOI) or any other prescription drug, or you are using an over-the-counter drug containing ingredients found in certain allergy, asthma, cough/cold and weight control products.

Stizm Supplement Facts
Serving Size: 2 Capsules
Servings per Container: 45
Amount per Serving
Caffeine 250mg
Theobromine 200mg
Synephrine HCL 100mg
Octopamine 100mg
Hordenine 100mg
Tyramine HCL 100mg
Phenylethylamine 50mg

Stizm Suggested Use:
As an adult dietary supplement take two capsules with 8 ounces of water 30-45 minutes before your workout or whenever an increase in energy or mental clarity is desired.

The recommended dose of this product contains caffeine and should not be taken by individuals wishing to eliminate caffeine from their diet. Limit use of caffeine-containing foods and beverages while taking this product because too much caffeine may cause nervousness, irritability, sleeplessness, and occasionally, rapid heartbeat.

Exceeding recommended serving will not improve results.

Discontinue use and call a health care professional immediately if you experience rapid heartbeat, dizziness, severe headache, shortness of breath, or other similar symptoms.

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