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Cissus quadrangularis is an ancient medicinal plant native to the hotter parts of Ceylon and India.
It was prescribed in the ancient Ayurvedic texts as a general tonic.
Modern research has shed light on Cissus ability to help support bone health by showing it acts as a glucocorticoid antagonist (1,2).
Since anabolic/androgenic compounds are well known to act as antagonists to the glucocorticoid receptor as well as promote good bone health, it has been postulated that Cissus possesses anabolic and/or androgenic properties (1,3).
The typical recommended daily dosage of Cissus extract is between 500 and 1000 mg, depending on the concentration of the extract.
For the powder of the dried plant, the Ayurvedic texts recommend a dosage of 3 to 6 grams.
Safety studies in rats showed no toxic effects at dosages as high as 2000 mg/kg of body weight.
So not only is Cissus efficacious, it is also quite safe, in either the dried powder form or the commercially available extract.
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