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1Fast400 Propionyl L -Carnitine HCL Powder, 75 grams
Propionyl-L-Carnitine (PLCAR)is an esterified carnitine that has clinically shown potential healthand exercise benefits such as increasing energy via the transport offatty acids into muscle cellular mitochondria, stimulating energyproduction in ischaemic muscles during exercise by increasing citricacid cycle flux and stimulating pyruvate dehydrogenase activity,powerful activity as a scavenger against superoxide radicals,protection against lipid peroxidation, reducing chronic fatigue andsupporting male aging symptoms. Clinical Findings CFS Support: Propiony-l-carnitine effects were assessed on the symptoms of chronicfatigue syndrome (CFS). In an open, randomized study 2 g/dpropionyl-L-carnitine was given to CFS patients during 24 weeks. Effects were rated by clinical global impression of change. Secondaryendpoints were the Multidimensional Fatigue Inventory. Clinical globalimpression of change after treatment showed considerable improvement in63% in the PLCAR group. PLCAR significantly improved general fatigue (p=. 004). Study concluded that PLCAR had beneficial effects on overallmuscle fatigue. Clinical Findings Male Aging Support: A recent study compared testosterone undecanoate versuspropionyl-L-carnitine plus acetyl-L-carnitine and placebo in thetreatment of male aging symptoms. The assessed variables were totalprostate-specific antigen, prostate volume, peak systolic velocity,end-diastolic velocity, resistive index of cavernosal penile arteries,nocturnal penile tumescence, total and free testosterone, prolactin,luteinizing hormone, International Index of Erectile Function score,Depression Melancholia Scale score, fatigue scale score, and incidenceof side effects. Carnitines (propionyl and acetyl) significantlyimproved the peak systolic velocity, end-diastolic velocity, resistiveindex, nocturnal penile tumescence (night time erection), InternationalIndex of Erectile Function score, Depression Melancholia Scale score,and fatigue scale score. Carnitines proved significantly more activethan testosterone in improving nocturnal penile tumescence andInternational Index of Erectile Function score. Testosteronesignificantly increased the prostate volume and free and totaltestosterone levels and significantly lowered serum luteinizinghormone; carnitines did not. No drug significantly modifiedprostate-specific antigen or prolactin. carnitines proved to be activedrugs for the therapy of symptoms associated with male aging. Clinical Findings Antioxidant andLipid Peroxidation Support: A current investigation observed the possible protective effects of apowerful anti-oxidant propionyl L-carnitine (PLCAR) againstalcohol-induced gastric lesions in rats. Propionyl L-carnitineprevented alcohol-induced increase in thiobarbituric acid-reactivesubstances (TBARS), an index of lipid peroxidation. The propionylcarnitine ester also increased the gastric content of reducedglutathione (GSH), besides it increased the enzymatic activities ofgastric superoxide dismutase (SOD) and glutathione-S-transferase (GST). Based on these observations, it was concluded that PLCAR could partlyprotect gastric mucosa from alcohol-induced acute mucosal injury, andthese gastroprotective effects might be probably induced, at leastpartly, through anti-oxidant mechanisms. Clinical Findings Exercise and EnergySupport: An animal study indicated that supplementation with PLCAR (in combowith CoEnzyme Q10, Nicotinamide, riboflavin and pantothenic acid)elicits positive functional changes on motor performance of skeletal,cardiac and smooth muscles. Other studies looking at exerciseperformance on subjects (mostly with cardiovascular concerns(claudication, peripheral arterial disease û decreased oxygen and bloodflow to muscles) and deconditioning, indicated that walkingperformance, treadmill exercise performance and muscle strength can beincreased with 2g/day supplementation of propionyl-L-carnitine. Heat Sealed Container. References: 1. Exploratory open label, randomized study of acetyl- andpropiony-l-carnitine in chronic fatigue syndrome Psychosom Med. 2004 Mar-Apr;66(2):276-82 2. Carnitine versus androgen administration in the treatment of sexualdysfunction, depressed mood, and fatigue associated with male aging Urology. 2004 Apr;63(4):641-6. 3. Protective role of carnitine esters against alcohol-induced gastriclesions in rats. Pharmacol Res. 2003 Sep;48(3):285-90. 4. Enhancement of muscular performance by a coformulation ofpropionyl-L-carnitine, coenzyme Q10, nicotinamide, riboflavin andpantothenic acid in the rat. Physiol Behav. 2002 Jun 1;76(2):257-63. 5. Effect of propionyl-L-carnitine on exercise performance inperipheral arterial disease. Med Sci Sports Exerc. 2001 Sep;33(9):1415-22. 6. Propionyl-L-carnitine improves exercise performance and functionalstatus in patients with claudication. Am J Med. 2001 Jun 1;110(8):616-22. 7. Changes in skeletal muscle histology and metabolism in patientsundergoing exercise deconditioning: effect of propionyl-L-carnitine. Muscle Nerve. 1997 Sep;20(9):1115-20. <IMG SRC=http://www.
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