beta 2 agonists -- alpha 2 antagonists?

[bigboy67]

I have been reading up quite a bit lately on albuterol and clen and other products. the alb/clen are beta 2 agonists, and they do this and they do that and yackety yack dont talk back. as you can see i am not the most scientifically minded person (math and money are more my style) and i was wondering if i could possibly get a slightly dumbed down explanation on what exactly beta 2 agonists and alpha 2 antagonists actually do in the body. thanx guys.

[dinoiii]

Cliff Notes Version on Adrenergic Receptors:

Most Important Actions

Beta 1 - (1) Heart, think of it as affecting the heart (kinda in a speed up fashion)

Beta 2 - (2) Lungs, this kind of controls dilation/constriction of the bronchioles of the lungs (why albuterol does its job ok)

Beta 3 - Brown Fat (predominate)

Alpha 1 - Blood pressure, Prostate (BPH) alleviation of symptoms

Alpha 2 - Blood pressure (most important in adrenal medullary tumors known as Pheochromocytomas)



Make Sense? I think I made it pretty basic and focused on the major (only) effects - there are more - but the clinically significant ones are there.

Now - just think blockers or antagonists STOP the actions, agonists INCREASE the actions. Cool?

[bigboy67]

yeah that makes sense, but i thought the whole deal with the beta 2 agonists was that they helped turn fat into fatty acids for the body to burn up. am i wrong about that?

[dinoiii]

Sorry, forgot which forum we are on - not a pharmacology one, obviously. ;-)

Beta-2 receptors are in fact found on both fat and muscle cells - unfortunately, still NOT the major aciton really. By stimulating those receptors, you can mobilize FFAs and promote muscle wasting.

I talked about this in the past...look at this thread...it may get a bit complex which is why I talked about it above in a brief 2-sentence summary.

http://www.discountanabolics.com/forum/showthread.php?t=1559&highlight=beta+receptors
(LOOK AT POST #6)

[bigboy67]

very interesting, so there are studies showing ephedrine is a beta-3 agonist? i don't suppose you would know how to find those studies? i was under the impression that there hadn't been a compound found that was a beta-3 agonist. it may be possible though that since it effects all betas that it isnt considered a "pure beta-3 agonist"?

do you know how CL316,243 and CGP12177A did in the primate trials?

i know, i know lots of questions! so here's one more....
since ephedrine is a general beta agonist/alpha antagonist, and albuterol is a specific beta agonist, would'nt it make sense to stack the two for synergy?

crap, i think i am starting to get into this science thing :) i'll try and take it easy though, i wouldnt wanna take anybodies job as resident scientist **cough, dinoiii, cough** !! hehe, just kidding, you'll always be the man around here brudda

[bigboy67]

come on you science hounds, nobody has answers for this /\/\/\/\/\/\/\?

[Trans_Isomer]

very interesting, so there are studies showing ephedrine is a beta-3 agonist? i don't suppose you would know how to find those studies? i was under the impression that there hadn't been a compound found that was a beta-3 agonist. it may be possible though that since it effects all betas that it isnt considered a "pure beta-3 agonist"?

do you know how CL316,243 and CGP12177A did in the primate trials?

i know, i know lots of questions! so here's one more....
since ephedrine is a general beta agonist/alpha antagonist, and albuterol is a specific beta agonist, would'nt it make sense to stack the two for synergy?

crap, i think i am starting to get into this science thing :) i'll try and take it easy though, i wouldnt wanna take anybodies job as resident scientist **cough, dinoiii, cough** !! hehe, just kidding, you'll always be the man around here brudda

Not sure on everything you said, but ill post what I do know

Fat cells have both B1 and A2 receptors, the B1 receptors activate lipase which causes the fat cell to breakdown. A2s blocks lipase and encourage the formation of fat in the cell decrease the formation of norepinephrine at the nerve sites. So you basically lose a lot of fat at the places with lots of B1 receptors but not a lot is lost in the places with the A2 receptors.

Yohimbe is an A2 antagonist, ephedrine is beta agonist I think...