Founder
February 27th, 2005, 12:09 AM
CHEMICAL CORNER 101 BY BRUCE KNELLER</p>
Taking Novedex XT™ for a TEST drive!</p>
First things first. I have a confession to make: when I patented the two
unique anti-aromatase compounds found in Novedex XT™, I knew this product would
be really special. But until very recently, I didn’t fully grasp the scope of its
potential in the supplement industry (funding research and getting real data on
a product has a way of doing that). That said, I’d like to thank Rich Gaspari for
not only talking the talk, but for walking the walk. While his competitors hide
behind their computers and use smoke-and-mirror tactics to trick consumers into
thinking their products are best, Gaspari Nutrition proves the worth of its products
with hard science. Case in point - Novedex XT™.</p>
And one more thing, here’s a shout out to all the haters who’ve been flaming
this product and Gaspari Nutrition on various bodybuilding forums: it’s time to
pay the piper. We have data, and we’re ready to share it! In fact, we invite everyone
to compare this data (and graphs) to other similar, but less impressive data (and
graphs) on our competitors’ products. In the end, the conclusion is simple: Novedex
XT™ is the safest, most effective testosterone boosting, estrogen inhibiting product
on the planet.</p>
THE STUDY</p>
Gaspari Nutrition commissioned a well-known, independent clinical research
lab located within a medical center to run a four week, open-label, proof-of-concept,
pilot trial. The purpose of the study was to determine the effects of consuming
Novedex XT™ on basal (resting) levels of testosterone and estrogen. A secondary
purpose was to ascertain the safety of Novedex XT™ supplementation using standard
clinical markers of safety (i.e., comprehensive blood chemistry panels).</p>
THE METHODS</p>
Very simply, the researchers took a handful of guys with normal testosterone
levels and had them take the recommended dose of Novedex XT™ every night before
they went to bed. Subjects were required to maintain their normal training and dietary
habits during the study, and weren’t allowed to take any other supplements. Blood
samples were taken pre, and at weekly intervals (1, 2, 3, and 4 weeks) to document
any changes in androgens (total testosterone and bioavailable testosterone, measured
via radioimmunoassay) and estrogen (estradiol, measured via immunochemiluminometric
assay). Pre (week 0) and post (week 4) blood samples were also taken to measure
changes in blood lipids (total cholesterol, HDL, LDL, triglycerides), liver function
(ALT, AST, bilirubin), and kidney function (creatinine, BUN). All blood samples
were analyzed in duplicate by one of the largest independent clinical research laboratories
in the world, Laboratory Corporation of America (LabCorp).</p>
THE RESULTS</p>
From the very first dose, things started to happen quickly. Total and bioavailable
testosterone increased by over 50 and 100%, respectively, after the first week.
Even more impressive was the greater than 50% reduction in circulating estradiol!
As the weeks passed, these differences were magnified, and by the three-week mark,
total testosterone had increased by more than 200%, bioavailable testosterone increased
by almost 450%, and estradiol had decreased by 67%! Take a look at the following
graphs for details regarding the hormonal changes during the course of the study.</p>
SAFETY DATA
Variable - Pre (week 0) - Post (week 4)</p>
Total Cholesterol (mg/dl) - 165 - 174</p>
HDL(mg/dl) - 55 - 56</p>
LDL (mg/dl) - 93 - 99</p>
Triglycerides (mg/dl) 88 - 93</p>
ALT (IU/L) - 31 - 33</p>
AST (IU/L) - 28 - 26</p>
Bilirubin (mg/dl) - 0.5 - 0.7</p>
Creatinine (mg/dl) - 1.1 - 1.0</p>
BUN (mg/dl) - 16 - 17</p>
</p>
Note: all safety variables remained within normal clinical limits for all subjects.</p>
THE CONCLUSION</p>
Results don’t get much easier to interpret than this. Novedex XT™ has the
double-barrel effect of jacking total and bioavailable testosterone while simultaneously
crippling estradiol. And it does it right out of the gate (i.e., within a few weeks).
When was the last time you could get these kind of effects from a safe, naturally
occurring combination of compounds? The answer is never.</p>
Let’s put this in perspective with a quick comparison to what we know about other
legal testosterone boosters and anti-estrogens:</p>
• Tribulis terrestris: increases total testosterone by 40-50% for a few hours
at best. No anti-aromatase activity.</p>
• Eurycoma longifolia: increases free testosterone up to 60%, but takes four
weeks to do it. No anti-aromatase activity.</p>
• Category leading anti-aromatase: increases total testosterone up to 188% and
free testosterone up to 226% within three weeks. Little, if any, anti-aromatase
activity, based on blood measurements of estradiol.</p>
• Novedex XT™: increases total testosterone by 211% and bioavailable testosterone*
(free T + weakly bound T) by 449% within three weeks. Potent anti-aromatase activity,
i.e., decreases circulating estradiol by 67% within two weeks.</p>
WHAT’S NEXT?</p>
We’re glad you asked that question. Rather than rest on our collective asses,
Gaspari Nutrition has already agreed to take the next logical step in the research
process: fund a placebo-controlled, double-blind study at one of the premier sports
nutrition laboratories in the country. This independent university trial will document
the effects of supplementing with Novedex XT™ during an eight-week training period.
Subjects will consist of healthy, resistance-trained men between the ages of 21-45
years. This time, we are pulling out all the stops to document the power and safety
of Novedex XT™. Researchers will measure anthropometric variables (total body weight,
percent body fat, fat mass, fat-free mass via DEXA), hemodynamic variables (heart
rate, blood pressure, rate pressure product), serum hormone variables (total and
free testosterone, dihydrotestosterone, estradiol, estrione, estrone, sex hormone
binding globulin, leutinizing hormone, follicle stimulating hormone, IGF-1, cortisol)
and serum and urinary clinical marker variables (prostate specific antigen, glucose,
total protein, blood urea nitrogen, creatinine, BUN/creatinine ratio, uric acid,
AST, ALT, CK, LDH, GGT, albumin, globulin, sodium, chloride, calcium, carbon dioxide,
total bilirubin, alkaline phosphatase, triglycerides, cholesterol, HDL, LDL, hemoglobin,
hematocrit, red blood cell counts, MCV, MCH, MCHC, RDW, neutrophils, lymphocytes,
monocytes, eosinophils, basophils).</p>
Obviously, we’re serious about this. And you be should too. Once you ditch all
the marketing hype, the science speaks for itself. Novedex XT™ is clearly in a class
by itself…</p>
Note: Bioavailable testosterone = free testosterone + weakly (albuminbound) testosterone.
The rapid dissociation of “weakly bound” testosterone from albumin results in the
availability of essentially all albumin-bound testosterone for steroid receptor
interaction. In contrast, bioavailable T does not include SHBG-bound testosterone,
because the SHBG-bound fraction is biologically inactive due to the high binding
affinity of SHBG for testosterone. See the following reference for details:</p>
PARDRIDGE WM. TRANSPORT OF PROTEIN-BOUND HORMONES INTO TISSUES IN VIVO. ENDOCR
REV 1981 2(1):103-123.</p>
Taking Novedex XT™ for a TEST drive!</p>
First things first. I have a confession to make: when I patented the two
unique anti-aromatase compounds found in Novedex XT™, I knew this product would
be really special. But until very recently, I didn’t fully grasp the scope of its
potential in the supplement industry (funding research and getting real data on
a product has a way of doing that). That said, I’d like to thank Rich Gaspari for
not only talking the talk, but for walking the walk. While his competitors hide
behind their computers and use smoke-and-mirror tactics to trick consumers into
thinking their products are best, Gaspari Nutrition proves the worth of its products
with hard science. Case in point - Novedex XT™.</p>
And one more thing, here’s a shout out to all the haters who’ve been flaming
this product and Gaspari Nutrition on various bodybuilding forums: it’s time to
pay the piper. We have data, and we’re ready to share it! In fact, we invite everyone
to compare this data (and graphs) to other similar, but less impressive data (and
graphs) on our competitors’ products. In the end, the conclusion is simple: Novedex
XT™ is the safest, most effective testosterone boosting, estrogen inhibiting product
on the planet.</p>
THE STUDY</p>
Gaspari Nutrition commissioned a well-known, independent clinical research
lab located within a medical center to run a four week, open-label, proof-of-concept,
pilot trial. The purpose of the study was to determine the effects of consuming
Novedex XT™ on basal (resting) levels of testosterone and estrogen. A secondary
purpose was to ascertain the safety of Novedex XT™ supplementation using standard
clinical markers of safety (i.e., comprehensive blood chemistry panels).</p>
THE METHODS</p>
Very simply, the researchers took a handful of guys with normal testosterone
levels and had them take the recommended dose of Novedex XT™ every night before
they went to bed. Subjects were required to maintain their normal training and dietary
habits during the study, and weren’t allowed to take any other supplements. Blood
samples were taken pre, and at weekly intervals (1, 2, 3, and 4 weeks) to document
any changes in androgens (total testosterone and bioavailable testosterone, measured
via radioimmunoassay) and estrogen (estradiol, measured via immunochemiluminometric
assay). Pre (week 0) and post (week 4) blood samples were also taken to measure
changes in blood lipids (total cholesterol, HDL, LDL, triglycerides), liver function
(ALT, AST, bilirubin), and kidney function (creatinine, BUN). All blood samples
were analyzed in duplicate by one of the largest independent clinical research laboratories
in the world, Laboratory Corporation of America (LabCorp).</p>
THE RESULTS</p>
From the very first dose, things started to happen quickly. Total and bioavailable
testosterone increased by over 50 and 100%, respectively, after the first week.
Even more impressive was the greater than 50% reduction in circulating estradiol!
As the weeks passed, these differences were magnified, and by the three-week mark,
total testosterone had increased by more than 200%, bioavailable testosterone increased
by almost 450%, and estradiol had decreased by 67%! Take a look at the following
graphs for details regarding the hormonal changes during the course of the study.</p>
SAFETY DATA
Variable - Pre (week 0) - Post (week 4)</p>
Total Cholesterol (mg/dl) - 165 - 174</p>
HDL(mg/dl) - 55 - 56</p>
LDL (mg/dl) - 93 - 99</p>
Triglycerides (mg/dl) 88 - 93</p>
ALT (IU/L) - 31 - 33</p>
AST (IU/L) - 28 - 26</p>
Bilirubin (mg/dl) - 0.5 - 0.7</p>
Creatinine (mg/dl) - 1.1 - 1.0</p>
BUN (mg/dl) - 16 - 17</p>
</p>
Note: all safety variables remained within normal clinical limits for all subjects.</p>
THE CONCLUSION</p>
Results don’t get much easier to interpret than this. Novedex XT™ has the
double-barrel effect of jacking total and bioavailable testosterone while simultaneously
crippling estradiol. And it does it right out of the gate (i.e., within a few weeks).
When was the last time you could get these kind of effects from a safe, naturally
occurring combination of compounds? The answer is never.</p>
Let’s put this in perspective with a quick comparison to what we know about other
legal testosterone boosters and anti-estrogens:</p>
• Tribulis terrestris: increases total testosterone by 40-50% for a few hours
at best. No anti-aromatase activity.</p>
• Eurycoma longifolia: increases free testosterone up to 60%, but takes four
weeks to do it. No anti-aromatase activity.</p>
• Category leading anti-aromatase: increases total testosterone up to 188% and
free testosterone up to 226% within three weeks. Little, if any, anti-aromatase
activity, based on blood measurements of estradiol.</p>
• Novedex XT™: increases total testosterone by 211% and bioavailable testosterone*
(free T + weakly bound T) by 449% within three weeks. Potent anti-aromatase activity,
i.e., decreases circulating estradiol by 67% within two weeks.</p>
WHAT’S NEXT?</p>
We’re glad you asked that question. Rather than rest on our collective asses,
Gaspari Nutrition has already agreed to take the next logical step in the research
process: fund a placebo-controlled, double-blind study at one of the premier sports
nutrition laboratories in the country. This independent university trial will document
the effects of supplementing with Novedex XT™ during an eight-week training period.
Subjects will consist of healthy, resistance-trained men between the ages of 21-45
years. This time, we are pulling out all the stops to document the power and safety
of Novedex XT™. Researchers will measure anthropometric variables (total body weight,
percent body fat, fat mass, fat-free mass via DEXA), hemodynamic variables (heart
rate, blood pressure, rate pressure product), serum hormone variables (total and
free testosterone, dihydrotestosterone, estradiol, estrione, estrone, sex hormone
binding globulin, leutinizing hormone, follicle stimulating hormone, IGF-1, cortisol)
and serum and urinary clinical marker variables (prostate specific antigen, glucose,
total protein, blood urea nitrogen, creatinine, BUN/creatinine ratio, uric acid,
AST, ALT, CK, LDH, GGT, albumin, globulin, sodium, chloride, calcium, carbon dioxide,
total bilirubin, alkaline phosphatase, triglycerides, cholesterol, HDL, LDL, hemoglobin,
hematocrit, red blood cell counts, MCV, MCH, MCHC, RDW, neutrophils, lymphocytes,
monocytes, eosinophils, basophils).</p>
Obviously, we’re serious about this. And you be should too. Once you ditch all
the marketing hype, the science speaks for itself. Novedex XT™ is clearly in a class
by itself…</p>
Note: Bioavailable testosterone = free testosterone + weakly (albuminbound) testosterone.
The rapid dissociation of “weakly bound” testosterone from albumin results in the
availability of essentially all albumin-bound testosterone for steroid receptor
interaction. In contrast, bioavailable T does not include SHBG-bound testosterone,
because the SHBG-bound fraction is biologically inactive due to the high binding
affinity of SHBG for testosterone. See the following reference for details:</p>
PARDRIDGE WM. TRANSPORT OF PROTEIN-BOUND HORMONES INTO TISSUES IN VIVO. ENDOCR
REV 1981 2(1):103-123.</p>