Can Clen reduce the effects of adrenaline?

[2BigBeastguy0]

So my fiance has finally thrown me a question that stumped me. I was explaining how if she takes clenbuterol or albuterol she should only be on for a couple weeks and then take at least 2 weeks off because the beta receptors get kinda clogged. She asked if by taking clen and clogging up the beta receptors, can that inhibit the effects of epinephrine (adrenaline)? Don't know and couldn't find anything online about it. Maybe adrenaline doesn't attach to the beta 2 receptor and at least can attach to another beta receptor? Thanks for any help.

[neonhypoxia]

Clogged really isn't the word, they just downregulate. Bascily they loose sensitivity. There are three beta receprots, and theire activity is closely related to each other. Clenbuterol and Albuterol are both Beta2 agonist, and while their effects are minimal on the other Beta receptors, they downregulate Beta2 receptors rather well. So while epi, norepi will still act on the other Betas fine, their activity on the Beta2s will be lowered until they upregulate back to homeostasis, producing a lower net effect. So yes, when you stop using clenbuterol or albuterol you will see overall a lower effect from epi and norepi for a few days.

Epinephrine and norepinephine are collectively refered to as adrenaline in common public terms, however there isn't really an adrenaline. Epi and norepi are closely related, however they are two seperate chemicals with somewhat different effects.

[2BigBeastguy0]

Awesome! Thanks!