Trans_Isomer
November 19th, 2005, 01:20 PM
PCT- The hows and the whats answered!
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Bet many of you here are well aware that you defenitely need a PCT after a cycle of something hormonal like 1AD, 1-T, m1t, m5 or even SD. There are any number of threads that tell you to take nolva, 6oxo, clomid, R-Xt. This thread is dedicated for those who are really interested to know why someone asks you to do that PCT and what exactly happens to your body during a PCT.
So why do I need to take all this stuff after my cycle?
During a cycle of AAS, natural production of testosterone decreases, often times to zero. In many cases, the diminished natural testosterone production causes a cessation of sperm production (spermatogenesis), and the male becomes sterile. After the cycle, the body's ability to make testosterone may take months to start again. Aside from the undesirable sterility and loss of strength, other hormone levels get out of whack because of the low testosterone, and cause other problems such as increased body fat and depression. The body produces many hormones, and the levels of most hormones are interrelated. This article will examine the factors involved in regulating the production of certain hormones in the body, particularly by the Hypothalamic-Pituitary-Testicular Axis
So what's the big deal in taking so many different compounds together?
The ideal post cycle therapy consists of a three compound administration which is designed so that there is a primary and secondary LH stimulator which both are maximizing potential early in the duration;
With the addition of an Aromatase Inhibitor, which makes the above possible, the individual will also endure less of an increase in Sex Hormone Binding Globulin, which allows free testosterone levels to reach base line at a much quicker pace. The individual will also see less of a problem in most cases with sexual libido as the bounding SHBG is controlled (to an extent).
Day 1-15 600 MG 6oxo + 100mg Clomid + 40mg Nolva
Day 16-30 300mg 6oxo + 75mg Clomid + 20mg Nolva
Selective estrogen receptor modulators(SERMs) such as Clomiphine and Tamoxifen are selective to which tissues they bind too.
Clomid being selective to the suprapituitary
Tamox is selective to breast, bone, and liver ERs
In studies showing levels of LH, FSH, and Testosterone checked after short durations of tamox, they were either insignificant, or their was an actual drop. I believe this is because tamox selectively works at the mammery(as well as bone and liver), thus taking longer for LH stimulation to occur.
With clomid, benefit to gonadotrophin concentrations, LH, FSH, and serum testosterone can be seen in short periods of 2-6wks. Because of the apparent selective nature of the two, and given our usual PCT duration, clomid is by far superior at LH stimulation than Nolva. Now both is the wise choice for a couple of reasons:
1. Nolva acts as the preventive measure to the estrogen flux occured PC while clomid is the primary LH stimulator(Even more so in the case an AI is not used).
2. If your running a longer PCT, clomid needs to be discontinued after a while as it has been shown to desensitize GnRH, this due, IMO, to it's selective nature to the suprapituitary. In the longer forms of PCT, the clomid will be phased out, leaving Nolva and 6oxo.
So after my PCT what should I expect from my body?
Hormone panel:
Testosterone: normal range 300 - 1200ng/dl
Free testosterone: normal range 8.7 - 25pg/ml
IGF-1: normal range 109-284ng/ml
Estradiol: normal range 5 - 53pg/ml
DHEA-s: normal range 120 - 520ug/dl
Thyroid panel:
T4: normal range 4.5 - 12ug/dl
T3: normal range 2.3 - 4.2pg/ml
TSH: normal range 0.350 - 5.500uIU/ml
Blood Lipid panel:
Total cholesterol: normal healthy range 100 - 199mg/dl
LDL fraction: normal range 0 - 99mg/dl
HDL fraction: normal range 40 - 59mg/dl
Triglycerides: normal range 0 - 149mg/dl
C-reactive protein: > 2mg/l increased risk of MI and stroke
Homocysteine: normal range 6.3 - 15umol/L
Liver function:
Alkaline phosphatase: Normal range 25 - 150IU/L
GGT: normal range 0 - 65IU/L
SGOT: normal range 0 - 40IU/L
SGPT: normal range 0-40IU/L
PSA: normal 0.0 - 4.0ng/ml
Renal function tests:
Creatinine: normal 0.5 - 1.5mg/dl
BUN: normal range 5 - 26mg/dl
Creatinine/BUN ratio: normal 8 - 27
What else can I take with all my ancillaries for a good PCT
Tribulus, ZMA are good to add on a PCT. Ideally you want to start these in the beginning of week 2 when the natural test levels are catching up.
I am not a doctor neither do I give medical advise.I just post what I have researched and obtained. If I am wrong please feel free to correct me.Thx
Many thanks to LMR and AM.
----------------------------------
Thanks to Anabolic Xtreme Krzna for the information.
--------------------------------------------------------------------------------
Bet many of you here are well aware that you defenitely need a PCT after a cycle of something hormonal like 1AD, 1-T, m1t, m5 or even SD. There are any number of threads that tell you to take nolva, 6oxo, clomid, R-Xt. This thread is dedicated for those who are really interested to know why someone asks you to do that PCT and what exactly happens to your body during a PCT.
So why do I need to take all this stuff after my cycle?
During a cycle of AAS, natural production of testosterone decreases, often times to zero. In many cases, the diminished natural testosterone production causes a cessation of sperm production (spermatogenesis), and the male becomes sterile. After the cycle, the body's ability to make testosterone may take months to start again. Aside from the undesirable sterility and loss of strength, other hormone levels get out of whack because of the low testosterone, and cause other problems such as increased body fat and depression. The body produces many hormones, and the levels of most hormones are interrelated. This article will examine the factors involved in regulating the production of certain hormones in the body, particularly by the Hypothalamic-Pituitary-Testicular Axis
So what's the big deal in taking so many different compounds together?
The ideal post cycle therapy consists of a three compound administration which is designed so that there is a primary and secondary LH stimulator which both are maximizing potential early in the duration;
With the addition of an Aromatase Inhibitor, which makes the above possible, the individual will also endure less of an increase in Sex Hormone Binding Globulin, which allows free testosterone levels to reach base line at a much quicker pace. The individual will also see less of a problem in most cases with sexual libido as the bounding SHBG is controlled (to an extent).
Day 1-15 600 MG 6oxo + 100mg Clomid + 40mg Nolva
Day 16-30 300mg 6oxo + 75mg Clomid + 20mg Nolva
Selective estrogen receptor modulators(SERMs) such as Clomiphine and Tamoxifen are selective to which tissues they bind too.
Clomid being selective to the suprapituitary
Tamox is selective to breast, bone, and liver ERs
In studies showing levels of LH, FSH, and Testosterone checked after short durations of tamox, they were either insignificant, or their was an actual drop. I believe this is because tamox selectively works at the mammery(as well as bone and liver), thus taking longer for LH stimulation to occur.
With clomid, benefit to gonadotrophin concentrations, LH, FSH, and serum testosterone can be seen in short periods of 2-6wks. Because of the apparent selective nature of the two, and given our usual PCT duration, clomid is by far superior at LH stimulation than Nolva. Now both is the wise choice for a couple of reasons:
1. Nolva acts as the preventive measure to the estrogen flux occured PC while clomid is the primary LH stimulator(Even more so in the case an AI is not used).
2. If your running a longer PCT, clomid needs to be discontinued after a while as it has been shown to desensitize GnRH, this due, IMO, to it's selective nature to the suprapituitary. In the longer forms of PCT, the clomid will be phased out, leaving Nolva and 6oxo.
So after my PCT what should I expect from my body?
Hormone panel:
Testosterone: normal range 300 - 1200ng/dl
Free testosterone: normal range 8.7 - 25pg/ml
IGF-1: normal range 109-284ng/ml
Estradiol: normal range 5 - 53pg/ml
DHEA-s: normal range 120 - 520ug/dl
Thyroid panel:
T4: normal range 4.5 - 12ug/dl
T3: normal range 2.3 - 4.2pg/ml
TSH: normal range 0.350 - 5.500uIU/ml
Blood Lipid panel:
Total cholesterol: normal healthy range 100 - 199mg/dl
LDL fraction: normal range 0 - 99mg/dl
HDL fraction: normal range 40 - 59mg/dl
Triglycerides: normal range 0 - 149mg/dl
C-reactive protein: > 2mg/l increased risk of MI and stroke
Homocysteine: normal range 6.3 - 15umol/L
Liver function:
Alkaline phosphatase: Normal range 25 - 150IU/L
GGT: normal range 0 - 65IU/L
SGOT: normal range 0 - 40IU/L
SGPT: normal range 0-40IU/L
PSA: normal 0.0 - 4.0ng/ml
Renal function tests:
Creatinine: normal 0.5 - 1.5mg/dl
BUN: normal range 5 - 26mg/dl
Creatinine/BUN ratio: normal 8 - 27
What else can I take with all my ancillaries for a good PCT
Tribulus, ZMA are good to add on a PCT. Ideally you want to start these in the beginning of week 2 when the natural test levels are catching up.
I am not a doctor neither do I give medical advise.I just post what I have researched and obtained. If I am wrong please feel free to correct me.Thx
Many thanks to LMR and AM.
----------------------------------
Thanks to Anabolic Xtreme Krzna for the information.