Anti-inflammatory supplements

[UNCfan1]

Ok quick question here. Anti-inflammatory drugs and supplements decrease protein synthesis. To how much of a degree are we talking about? I was planning to trying out some Resveratrol with my next DMT run. For its benefits on heart enlargement.

[UNCfan1]

Bump, Dinoiii, Voodoo, Sol anyone?

[dinoiii]

Ok quick question here. Anti-inflammatory drugs and supplements decrease protein synthesis. To how much of a degree are we talking about? I was planning to trying out some Resveratrol with my next DMT run. For its benefits on heart enlargement.

In vivo experiments have trickled in but usually based on some fundamentally-flawed rat studies (like those with partial nephrectomies - a nephron is the functional unit of the kidney and a portion of the kidneys has been removed in these such experiments to induce hypertension without a control mechanism like angiotensin/aldosterone, etc...). How this applies to the general populace is PURELY ADVERTISEMENT to date and NOTHING MORE! Resveratrol has a very LOW bioavailability and many supplements still fail to standardize the appropriate level of the trans-isomer required to see such effects should they be mimicked, however...as I assume your kidneys to be normal, you may be unimpressed overall with its effects.

Recently researchers at the University of Connecticut conducted an experiment to determine any potential benefits from resveratrol in regard to heart failure. The aortic banding technique was employed in laboratory rats for 4 weeks, which produced changes in heart rate, pumping action and shape (enlargement) of the heart. Another group of laboratory rats whose aortas were banded were given trans resveratrol (2.5 milligrams per kilogram of body weight, or the equivalent of 175 milligrams for a 170-pound human). Resveratrol “completely abolished development of heart enlargement” with no change in the thickness of the heart wall. The pumping action (ejection fraction) of the heart was minimally reduced and the heart rate was not affected. [American Journal Physiology Heart Circulatory Physiology 292: H2138-43, May 2007]


The long and short of your initial question however, is that the rates of decline in protein synthesis will vary dependent on which protein we are talking about. If you are specifically asking about muscle protein synthesis (but joint, cartilage, etc... also is hampered to a degree), this can be altered by specific timing protocols of anti-inflammatory agents...of which ... all agents should NOT be considered equal and they should also be assumed to affect different pathways.


D_

[nojoke]

The long and short of your initial question however, is that the rates of decline in protein synthesis will vary dependent on which protein we are talking about. If you are specifically asking about muscle protein synthesis (but joint, cartilage, etc... also is hampered to a degree), this can be altered by specific timing protocols of anti-inflammatory agents...of which ... all agents should NOT be considered equal and they should also be assumed to affect different pathways.


D_

Were dosages with the anti's of any significance as well?



NJ

[UNCfan1]

Thanks D for chiming in. Hope u had a great vacation. I have read that it had very low bioavailability which kinda turned me away for now. Thanks for clearing up the anti-inflammatory question.